Retinoic Acid Induced Protein 14 (Rai14) is dispensable for mouse spermatogenesis
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چکیده
منابع مشابه
RAI14 (retinoic acid induced protein 14) is an F-actin regulator
RAI14 (retinoic acid induced protein 14) is an actin-binding protein first identified in the liver. In the testis, RAI14 is expressed by both Sertoli and germ cells in the seminiferous epithelium. Besides binding to actin in the testis, RAI14 is also a binding protein for palladin, an actin cross-linking and bundling protein. A recent report has shown that RAI14 displays stage-specific and spat...
متن کاملThe cellular retinoic acid binding protein I is dispensable.
The cellular retinoic acid binding proteins I and II (CRABPI and CRABPII) bind retinoic acid with high affinity, exhibit distinct patterns of expression during embryonic development, and are thought to play important roles in the RA signaling pathway. We have generated a targeted mutation of the CRABPI gene using the "hit-and-run" strategy and shown that it prevents the production of a function...
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Rai14 (retinoic acid induced protein 14) is an actin binding protein first identified in the liver, highly expressed in the placenta, the testis, and the eye. In the course of studying actin binding proteins that regulate the organization of actin filament bundles in the ectoplasmic specialization (ES), a testis-specific actin-rich adherens junction (AJ) type, Rai14 was shown to be one of the r...
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Spermatogenesis in adult mammals is highly organized, with the goal being the uninterrupted production of sperm. How continual, asynchronous sperm production is initiated and maintained in the mammalian testis is still under investigation but retinoic acid (RA) likely plays a key role. Investigations utilizing vitamin A deficient rodents, transgenic mouse models, whole testis and isolated germ ...
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Retinoic acid (RA) is thought to play a role in embryonic pattern formation in vertebrates. A naturally occurring gradient of endogenous RA has been demonstrated in the developing chick limb bud, while local application of RA leads to the formation of additional digits. In mammals, a well-defined spectrum of birth defects has been reported as a result of fetal exposure to excess RA. In analogy ...
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ژورنال
عنوان ژورنال: PeerJ
سال: 2021
ISSN: 2167-8359
DOI: 10.7717/peerj.10847